The pathways by which mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury

The pathways by which mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury

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Several studies have demonstrated that mild hypothermia exhibits a neuroprotective role and it can inhibit endothelial cell apoptosis following ischemia/reperfusion injury by decreasing casp-ase-3 expression.It is hypothesized that mild hypothermia exhibits neuroprotective bail shoulder bag effects on neurons exposed to ischemia/reperfusion condition produced by oxygen-glucose deprivation.Mild hypothermia significantly reduced the number of apoptotic neurons, decreased the expression of pro-apoptotic protein Bax and increased mitochondrial membrane potential, with the peak of anti-apoptotic effect appearing between 6 and 12 hours after the injury.These findings etc ufmp8 indicate that mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury by protecting the mitochondria and that the effective time window is 6-12 hours after ischemia/reperfusion injury.